2010 Reserve Fixtures
| Date | Fixture | Comp | Gate | Result | Scorers | |
| 14/08/2010 | Monk F.C. v Maine Road | Cheshire L 2nd Div. | 0 | 4 - 2 | Danny Clare (25) Ian Maitland (65) |  |
| 18/08/2010 | Runcorn Town Reserves v Maine Road | Cheshire L 2nd Div. | 0 | 4 - 1 | R Nevins (77) | |
| 18/08/2010 | Abbey Hey v Maine Road | Cheshire L 2nd Div. | ||||
| 21/08/2010 | Whitchurch A v Maine Road | Cheshire L 2nd Div. | 0 | 4 - 1 | James McQuillan (0) | |
| 25/08/2010 | Maine Road v Rudheath Social | Cheshire L 2nd Div. | 0 | 2 - 0 | Alistair Holden (15) Olayinka Ola (68) | |
| 28/08/2010 | Grappenhall Sports v Maine Road | Cheshire L 2nd Div. | 0 | 6 - 2 | James McQuillan (0) Alistair Holden (0) | |
| 01/09/2010 | Denton Town v Maine Road | Cheshire L 2nd Div. | 0 | 2 - 1 | R Nevins (0) | |
| 04/09/2010 | Poynton v Maine Road | Cheshire L 2nd Div. | 0 | 0 - 0 | | |
| 11/09/2010 | Maine Road v Runcorn Town Reserves | Cheshire L 2nd Div. | 0 | 1 - 2 | Danny Clare (0) | |
| 15/09/2010 | Maine Road v Crewe F.C. | Cheshire L 2nd Div. | 0 | 0 - 0 | | |
| 18/09/2010 | Daten v Maine Road | Cheshire L 2nd Div. | 0 | 7 - 1 | Josh Gittings (0) | |
| 25/09/2010 | Maine Road v Barnton | Cheshire L 2nd Div. | 0 | 2 - 2 | James McQuillan (0) R Nevins (0) | |
| 02/10/2010 | Denton Town v Maine Road | C.L.Div 2 Challenge Cup | 0 | 1 - 2 | Thomas Johnson (0) Joshua Stannicki (0) | |
| 16/10/2010 | Maine Road v Monk F.C. | Cheshire L 2nd Div. | 0 | 6 - 0 | Dilan Lomas (0) Thomas Johnson (0) Thomas Johnson (0) J. Sumner (0) Alistair Holden (0) Alistair Holden (0) | |
| 23/10/2010 | Malpas v Maine Road | Cheshire L 2nd Div. | 0 | 4 - 3 | James McQuillan (0) Thomas Johnson (0) Lewis Schofield (0) | |
| 30/10/2010 | Maine Road v Poynton | Cheshire L 2nd Div. | 0 | 2 - 4 | James McQuillan (0) Thomas Johnson (0) | |
| 06/11/2010 | Crewe F.C. v Maine Road | Cheshire L 2nd Div. | 0 | 4 - 1 | | |
| 13/11/2010 | Congleton Town Reserves v Maine Road | Cheshire L 2nd Div. | 0 | 5 - 0 | ||
| 20/11/2010 | Maine Road v Moore United | Cheshire L 2nd Div. | 0 | 3 - 5 | R Nevins (0) R Nevins (0) R Nevins (0) | |
| 27/11/2010 | Curzon Ashton v Maine Road | Manchester ChallengeTrophy | 0 | 4 - 1 | Ed Wileman (5) | |
| 11/12/2010 | Poynton v Maine Road | Cheshire L 2nd Div. | 0 | 3 - 2 | Declan.O'Shea (35) Alistair Holden (65) | |
| 08/01/2011 | Barnton v Maine Road | Cheshire L 2nd Div. | 0 | 5 - 1 | Thomas Johnson (0) | |
| 02/02/2011 | Maine Road v Grappenhall Sports | Cheshire L 2nd Div. | 0 | 2 - 6 | ||
| 09/02/2011 | Maine Road v Daten | Cheshire L 2nd Div. | 0 | 3 - 1 | ||
| 12/02/2011 | Maine Road v Whitchurch A | C.L.Div 2 Challenge Cup | 0 | 1 - 2 | Matt Dodwell (0) | |
| 19/02/2011 | Rudheath Social v Maine Road | Cheshire L 2nd Div. | 0 | 8 - 0 | ||
| 12/03/2011 | Maine Road v Whitchurch A | Cheshire L 2nd Div. | 0 | 2 - 1 | Ian Maitland (0) Joseph Newbold (0) | |
| 24/03/2011 | Maine Road v Congleton Town Reserves | Cheshire L 2nd Div. | 0 | 1 - 2 | Kevin Dimingo (0) | |
| 26/03/2011 | Moore United v Maine Road | Cheshire L 2nd Div. | 0 | 2 - 1 | Olayinka Ola (0) | |
| 09/04/2011 | Maine Road v Denton Town | Cheshire L 2nd Div. | 0 | 1 - 4 | Ian Maitland (0) | |
| 16/04/2011 | Maine Road v Malpas | Cheshire L 2nd Div. | 0 | 4 - 4 | Kevin Dimingo (0) Tom Scoble (0) Chris Jepson (0) Chris Jepson (0) |
